MODULATORY EFFECT OF METFORMIN AND ARTEMETHER-LUMEFANTRINE ON BLOOD COAGULATION IN DIABETIC MICE CO-INFECTED WITH MALARIA
- Project Research
- 1-5 Chapters
- Qualitative
- Library / Doctrinal
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
Blood coagulation is a process describing conversion of soluble materials within the blood into an insoluble gel that plugs injury/break site within blood vessels; this process requires regulation. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, defectiveness of insulin hormone has been found to have an increased risk of coagulation and can lead to cardiovascular disorders. Malaria is a disease caused by plasmodium parasite, when the parasite enters the bloodstream; proteins are secreted into the host’s red blood cells, which stick to other blood cells making them adherent to blood vessel walls reducing detection and destruction of infected blood cells by the immune system which potentially causes blood clots. Effect of anti-malaria drugs on blood coagulation has not been properly investigated, as diabetics have been found to have possible co-infection with malaria, this study aims to provide information on the modulation of blood coagulation by metformin and artemether-lumefantrine in diabetic mice co-infected with malaria.
Fifty albino mice (BALB/C strain) were divided into 8 groups for this study; group I served as the normal control, group II served as diabetes negative control, group III served as malaria only, group IV served as diabetes co-infected with malaria group, group V served as malaria treated with 6.86 mg/body weight of artemether-lumefantrine, group VI served as diabetes treated with 200 mg/body weight of metformin, group VII served as diabetes co-infected malaria and treated with 200 mg/body weight of metformin and group VIII served as diabetes co-infected with malaria and treated with 200 mg/body weight of metformin and 6.86 mg/body weight of artemether-lumefantrine.
The results showed artemether-lumefantrine having an anti-coagulant effect on prothrombin time of extrinsic factors in malaria positive treatment group, metformin having a pro-coagulant effect on intrinsic factors in diabetes positive control group, and artemether-lumefantrine elevating the fibrinogen concentration in malaria positive control group. These findings suggest that while metformin is the first-line drug with an anti-coagulant effect on diabetes, artemether-lumefantrine not only could cure plasmodium falciparum but also possesses an anticoagulant effect.
Keywords: Artemether-Lumefantrine, Blood coagulation, Diabetes, Malaria, Metformin
Related Project Materials
An Appraisal of Government Interventions in Improving Education Outcomes in Tudun Wada Local Government, Kano State
Chapter One: Introduction
1.1 Background of the Study
Education is widely recognized as a fundamental factor in the socio-econo...
The effect of competency-based assessment on STEM learning outcomes in Doma LGA, Nasarawa State
Background of the Study
Competency-based assessment (CBA) represents a paradigm shift in educational evaluation by fo...
An assessment of the role of rural-urban transportation in economic integration in Sapele Local Government Area, Delta State, Nigeria
Background of the study:
Transportation systems are essential for bridging the economic gap between rural and urban areas b...
STRATEGIES FOR IMPROVING LOW ACADEMIC PERFORMANCES IN ENGLISH LANGUAGE IN SECONDARY SCHOOL
Background of the study
The modern trend in education and the complex nature of learning and instruction have made the r...
An appraisal of adult literacy programs in reducing poverty levels in Wukari Local Government Area, Taraba State.
Background of the Study
Adult literacy programs have increasingly become a pivotal instrument for socio-economic transform...
Photography and Advocacy for Improved Housing in Jibia Local Government Area, Katsina State
Chapter One: Introduction
1.1 Background of the Study
Housing is a fundamental human need, playing a critical role in health, w...
An assessment of cybersecurity measures on safeguarding online banking transactions: a case study of Citibank Nigeria
Background of the Study :
In the digital age, the security of online banking transactions is paramount for protecting sensitive financial...
The Effect of Corporate Communication on Organizational Innovation: A Study of Numan Local Government Area, Adamawa State
Chapter One: Introduction
1.1 Background of the Study
Organizational innovation refers to the de...
The Effect of CEO Compensation on Financial Performance in Listed Companies in Taraba State
Background of the Study
CEO compensation, encompassing salaries, bonuses, stock options, and other financial incentives,...
The Impact of Updated Regulatory Frameworks on Strengthening Bank Governance in Nigeria: A Case Study of First Bank of Nigeria
Background of the Study
Robust regulatory frameworks are essential for ensuring transparency, stability, and sound governan...
